330005 Sigma-AldrichEST - CAS 88321-09-9 - Calbiochem
A cell-permeable, irreversible inhibitor of cysteine proteases.
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Sinónimos: Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d
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Descripción
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Tabla espec. clave
| CAS # | Empirical Formula |
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| 88321-09-9 | C₁₇H₃₀N₂O₅ |
Products
| Número de referencia | Embalaje | Cant./Env. | |
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| 330005-1MG | Ampolla de plást. | 1 mg |
| Description | |
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| Overview | A cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but devoid of charged groups. Reported to inhibit calpain-1 activation. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy. |
| Catalogue Number | 330005 |
| Brand Family | Calbiochem® |
| Synonyms | Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d |
| Product Information | |
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| CAS number | 88321-09-9 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₁₇H₃₀N₂O₅ |
| Chemical formula | C₁₇H₃₀N₂O₅ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | calpain-1 |
| Primary Target IC<sub>50</sub> | 10-100 µM for calpain-1 |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Safety Information according to GHS | |
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| RTECS | RR0404300 |
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| Specifications |
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| Global Trade Item Number | |
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| Número de referencia | GTIN |
| 330005-1MG | 04055977195699 |
Documentation
EST - CAS 88321-09-9 - Calbiochem Ficha datos de seguridad (MSDS)
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EST - CAS 88321-09-9 - Calbiochem Certificados de análisis
| Cargo | Número de lote |
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| 330005 |
Referencias bibliográficas
| Visión general referencias |
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| Inomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129. Mehdi, S. 1991. Trends Biochem. Sci. 16, 150. McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun. 158, 432. Tamai, M., et al. 1987. J. Pharmacobiodyn. 10, 678. Komatsu, K., et al. 1986. Exp. Neurol. 91, 23. Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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