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324461 E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem

The E2F Inhibitor, HLM006474, also referenced under CAS 353519-63-8, controls the biological activity of E2F. This small molecule/inhibitor is primarily used for Cancer applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 7-((4-Ethoxy-3-methylphenyl)(2-pyridylamino)methyl)-2-methyl-quinolinol

324461
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Descripción

Replacement Information

Products

Número de referenciaEmbalaje Cant./Env.
324461-10MG Frasco de vidrio 10 mg
Description
OverviewA cell-permeable 8-hydroxyquinoline compound that is reported to inhibit nuclear E2F complexes DNA binding activity (IC50 = 30 µM) and downregulate E2F expression in the melanoma cell line A375, resulting in eventual apoptosis induction without upregulating p53 expression as commonly seen with traditional chemotherapeutic agents, such as Cisplatin (Cat. No. 232120), doxorubicin (Cat. No. 324380), and VP-16 (Cat. No. 341205).
Catalogue Number324461
Brand Family Calbiochem®
Synonyms7-((4-Ethoxy-3-methylphenyl)(2-pyridylamino)methyl)-2-methyl-quinolinol
References
ReferencesMa, Y., et al. 2008. Cancer Res. 68, 6292.
Product Information
CAS number353519-63-8
FormOff-white solid
Hill FormulaC₂₅H₂₅N₃O₂
Chemical formulaC₂₅H₂₅N₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
324461-10MG 04055977197211

Documentation

E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem Certificados de análisis

CargoNúmero de lote
324461

Referencias bibliográficas

Visión general referencias
Ma, Y., et al. 2008. Cancer Res. 68, 6292.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2011 RFH
Synonyms7-((4-Ethoxy-3-methylphenyl)(2-pyridylamino)methyl)-2-methyl-quinolinol
DescriptionA cell-permeable 8-hydroxyquinoline compound that is reported to inhibit nuclear E2F complexes DNA binding activity (IC50 = 30 µM) and downregulate E2F expression in the melanoma cell line A375, resulting in eventual apoptosis induction without upregulating p53 expression as commonly seen with traditional chemotherapeutic agents, such as Cisplatin (Cat. No. 232120), doxorubicin (Cat. No. 324380), and VP-16 (Cat. No. 341205).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number353519-63-8
Chemical formulaC₂₅H₂₅N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMa, Y., et al. 2008. Cancer Res. 68, 6292.