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309866 Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem

Synthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: L-Type Calcium Channel Blocker II

309866
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Products

Número de referenciaEmbalaje Cant./Env.
309866-100MG Ampolla de plást. 100 mg
Description
OverviewSynthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca2+ release from intracellular stores in neutrophils.
Catalogue Number309866
Brand Family Calbiochem®
SynonymsL-Type Calcium Channel Blocker II
References
Referencesvan Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2792.
Gallizzi, J.P., et al. 1986. J. Biol. Chem. 261, 1393.
Garcia, M.L., et al. 1986. J. Biol. Chem. 261, 8146.
Product Information
CAS number33286-22-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₂H₂₆N₂O₄S · HCl
Chemical formulaC₂₂H₂₆N₂O₄S · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetL-type Ca2+ channel
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDL0310000
Safety Information
R PhraseR: 22-40

Harmful if swallowed.
Limited evidence of a carcinogenic effect.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
309866-100MG 04055977216820

Documentation

Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem Certificados de análisis

CargoNúmero de lote
309866

Referencias bibliográficas

Visión general referencias
van Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2792.
Gallizzi, J.P., et al. 1986. J. Biol. Chem. 261, 1393.
Garcia, M.L., et al. 1986. J. Biol. Chem. 261, 8146.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-April-2008 RFH
SynonymsL-Type Calcium Channel Blocker II
DescriptionSynthetic (+)-cis isomer that acts as an L-type Ca2+ channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca2+ release from intracellular stores in neutrophils.
FormWhite solid
CAS number33286-22-5
RTECSDL0310000
Chemical formulaC₂₂H₂₆N₂O₄S · HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (50 mg/ml), Methanol, or chloroform
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 3202
Referencesvan Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2792.
Gallizzi, J.P., et al. 1986. J. Biol. Chem. 261, 1393.
Garcia, M.L., et al. 1986. J. Biol. Chem. 261, 8146.