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SCC142 DC2.4 Mouse Dendritic Cell Line

DC2.4 dendritic cell line can be used to study dendritic cell biology and immune response.

DC2.4 Mouse Dendritic Cell Line : Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Key Applications: Cell Culture
SCC142
≥1X10⁶ cells/vial   
Purchase on Sigma-Aldrich

Descripción

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Key Applications
CULT
Description
Catalogue NumberSCC142
DescriptionDC2.4 Mouse Dendritic Cell Line
OverviewDC2.4 are immortalized murine dendritic cells created by transducing bone marrow isolates of C57BL/6 mice with retrovirus vectors expressing murine granulocyte-macrophage CSF (GM-CSF) and the myc and raf oncogenes (2). DC2.4 exhibits characteristic features of dendritic cells including cell morphology and the expression of dendritic cell-specific markers and the ability to phagocytose and present exogenous antigens on both MHC class I and class II molecules (2).
Alternate Names
  • DC 2.4 Cell Line
Background InformationDendritic cells (DC) are the antigen presenting cells of the immune system and are found in most tissues, particularly those that are in contact with the external environment (e.g., skin and the inner linings of the nose, lungs, stomach and intestine). First described in 1973 (1), one of the primary functions of DCs is to phagocytose foreign pathogens and present the processed antigens to naïve T cells to regulate adaptive immune responses. DCs also express Toll-like receptors and help regulate the innate immune responses. Despite their distribution in most tissues, DC are present at low numbers in vivo and are difficult to maintain in vitro. These difficulties have limited the studies of dendritic cells.

References
1. Steinman RM, Cohn ZA (1973) J Exp Med 137(5): 1142-1162.
2. Shen Z et al. (1997) J Immunol 158(6): 2723-2730.
References
Product Information
HS Code3002 90 99
Quality LevelMQ100
Applications
ApplicationDC2.4 dendritic cell line can be used to study dendritic cell biology and immune response.
Key Applications
  • Cell Culture
Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
Biological Information
Cell Line Type
  • Dendritic Cell Line
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance• Each vial contains ≥ 1X106 viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
Usage Statement
  • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Packaging Information
Material Size≥1X10⁶ cells/vial
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
SCC142 04054839344213