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204883 Complement C1-Esterase Inhibitor, Human

Complement C1-Esterase Inhibitor, Human, is a native, single-chain glycoprotein that is involved in regulation of complement, coagulation, fibrinolytic and contact systems of circulating plasma.

Complement C1-Esterase Inhibitor, Human: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
204883
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Descripción

Replacement Information

Products

Número de referenciaEmbalaje Cant./Env.
204883-1MG Ampolla de plást. 1 mg
Description
OverviewNative, human C1-esterase. Single-chain glycoprotein present in normal human serum at 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. The only known inhibitor of activated C1r and C1s complement enzymes. The presence of either hereditary or acquired deficiencies of C1 inhibitor produce susceptibility to recurrent attacks of angioedema.
Catalogue Number204883
Brand Family Calbiochem®
References
ReferencesBowen, B., et al. 2001. Clin. Immunol. 98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.
Product Information
FormLiquid
FormulationIn PBS, pH 7.3, sterile-filtered through a 0.22 µm filter.
PreservativeNone
Quality LevelMQ100
Applications
Application CommentsVariables associated with assay conditions will dictate the proper working dilution.
Biological Information
Biological activity≥80% of C1-esterase inhibitor will bind activated C1s.
Purity≥90% by SDS-PAGE
SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
ContaminantsIgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin: ≤trace amounts
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
204883-1MG 04055977219777

Documentation

Complement C1-Esterase Inhibitor, Human Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Complement C1-Esterase Inhibitor, Human Certificados de análisis

CargoNúmero de lote
204883

Referencias bibliográficas

Visión general referencias
Bowen, B., et al. 2001. Clin. Immunol. 98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-January-2020 JSW
DescriptionNative, human C1-esterase. Complent C1-esterase inhibitor purified from human plasma. Single chain glycoprotein present in normal human serum at a concentration of 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.
BackgroundSingle chain glycoprotein present in normal human serum at a concentration of 180 μg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.
FormLiquid
FormulationIn PBS, pH 7.3, sterile-filtered through a 0.22 µm filter.
Concentration Label Please refer to vial label for lot-specific concentration
SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity≥90% by SDS-PAGE
ContaminantsIgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin: ≤trace amounts
Biological activity≥80% of C1-esterase inhibitor will bind activated C1s.
PreservativeNone
CommentsVariables associated with assay conditions will dictate the proper working dilution.
Storage Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesBowen, B., et al. 2001. Clin. Immunol. 98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.