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219502 Cathepsin L Inhibitor, CAA0225 - Calbiochem

Cathepsin L Inhibitor, CAA0225 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
219502
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₈H₂₉N₃O₅

Products

Número de referenciaEmbalaje Cant./Env.
219502-1MG 1 mg
Description
OverviewAn epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
Catalogue Number219502
Brand Family Calbiochem®
References
ReferencesTakahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
Ueno, T., et al. 2009. Autophagy 5, 878.
Product Information
FormWhite solid
Hill FormulaC₂₈H₂₉N₃O₅
Chemical formulaC₂₈H₂₉N₃O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥ 95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
219502-1MG 04055977218039

Documentation

Cathepsin L Inhibitor, CAA0225 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Cathepsin L Inhibitor, CAA0225 - Calbiochem Certificados de análisis

CargoNúmero de lote
219502

Referencias bibliográficas

Visión general referencias
Takahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
Ueno, T., et al. 2009. Autophagy 5, 878.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-March-2011 RFH
DescriptionAn epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
FormWhite solid
Chemical formulaC₂₈H₂₉N₃O₅
Structure formulaStructure formula
Purity≥ 95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTakahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
Ueno, T., et al. 2009. Autophagy 5, 878.