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219362 Cathepsin B, Human Liver

219362
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Descripción

Products

Número de referenciaEmbalaje Cant./Env.
219362-50UG Ampolla de plást. 50 μg
Description
OverviewNative cathepsin B from human liver, purified by affinity chromatography and HPLC. The most investigated enzyme of all lysosomal cysteine proteases. Upregulation and secretion of cathepsin B have been shown to occur in many types of tumors and to correlate positively with their invasive and metastatic capabilities. Cathepsin B is shown to facilitate tumor invasion by dissolving extracellular barriers.
Catalogue Number219362
Brand Family Calbiochem®
References
ReferencesHirai, K., et al. 1999. Hum. Pathol. 30, 680.
Kostoulas, G., et al. 1999. FEBS Lett. 455, 286.
Strojnik, T., et al. 1999. Clin. Cancer Res. 5, 559.
Maquire, T.M., et al. 1998. Int. J. Biol. Markers 13, 139.
Berquim, I.M., and Sloane, B.F. 1996. Adv. Exp. Med. Biol. 389, 281.
Product Information
CAS number9047-22-7
Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-RR-β-naphthylamide per min at 40°C, using 100 mM Na<sup>+</sup>/K<sup>+</sup> pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.
EC number3.4.22.1
FormLiquid
FormulationIn 50 mM sodium acetate buffer, 1 mM EDTA, pH 5.0.
Quality LevelMQ100
Biological Information
Purity≥95% by SDS-PAGE
SourcePrepared from tissues of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥10 units/mg protein
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Global Trade Item Number
Número de referencia GTIN
219362-50UG 04055977202205