Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

208851 Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

Calyculin A, CAS 101932-71-2, is a cell-permeable inhibitor of protein phosphatase 2A (IC₅₀ = 0.5-1 nM) and protein phosphatase 1 (PP1; IC₅₀ = 2 nM).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: PP2A
208851
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
101932-71-2C₅₀H₈₁N₄O₁₅P

Products

Número de referenciaEmbalaje Cant./Env.
208851-10UG Frasco de vidrio 10 μg
Description
OverviewA cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC50 = 0.5-1 nM) and protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Also known to prevent γ-radiation induced apoptosis in Burkitt’s lymphoma cell line BM13674. Also available as a 100 µM solution in DMSO (Cat. No. 508226).
Catalogue Number208851
Brand Family Calbiochem®
References
ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
Product Information
CAS number101932-71-2
ATP CompetitiveN
FormClear film to white crystalline powder
Hill FormulaC₅₀H₈₁N₄O₁₅P
Chemical formulaC₅₀H₈₁N₄O₁₅P
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPP2A
Primary Target IC<sub>50</sub>0.5-1 nM and 2 nM against protein phosphatase 2A (PP2A) and protein phosphatase 1 (PP1)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25-38

Toxic by inhalation, in contact with skin and if swallowed.
Irritating to skin.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 12 months at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
208851-10UG 04055977219470

Documentation

Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem Certificados de análisis

CargoNúmero de lote
208851

Referencias bibliográficas

Visión general referencias
Murakami, N., et al. 1994. Neurosci. Lett. 176, 181.
Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure
Protein Phosphatases Technical Bulletin

Citas

Título
  • Carole M. Liedtke, Xiangyun Wang and Nicole D. Smallwood. (2005) Role for protein phosphatase 2A in the regulation of calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. Journal of Biological Chemistry 280, 25491-25498.
    		•
    Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision29-June-2011 JSW
    DescriptionCell-permeable protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.5-1.0 nM). Also inhibits protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Recently, it has been used to study the regulation of Ca2+-activated K+ channels in smooth muscle and to correlate shape changes in fibroblasts with the degree of protein phosphorylation. Also known to prevent γ-radiation induced apoptosis in Burkitt's lymphoma cell line BM13674.
    FormClear film to white crystalline powder
    Intert gas (Yes/No) Packaged under inert gas
    CAS number101932-71-2
    Chemical formulaC₅₀H₈₁N₄O₁₅P
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO or Ethanol (2 mg/ml)
    Storage Protect from light
    -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 12 months at 4°C.
    Toxicity Toxic
    ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
    Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
    Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
    Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
    Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
    Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
    Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
    Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
    Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
    Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
    Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
    Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
    Citation
  • Carole M. Liedtke, Xiangyun Wang and Nicole D. Smallwood. (2005) Role for protein phosphatase 2A in the regulation of calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. Journal of Biological Chemistry 280, 25491-25498.
    		•