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14-718M CaM Kinase IIβ Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, CaM Kinase IIβ, amino acids 1-315, for use in Kinase Assays.

14-718M
250 µg  Also available in 10 μg size (cat#14-718) and in bulk (cat#14-718-K).
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-718M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionCaM Kinase IIβ Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant, CaM Kinase IIβ, amino acids 1-315
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, CaM Kinase IIβ, amino acids 1-315, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Entrez Gene Number
Entrez Gene SummaryThe product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.
Gene Symbol
  • CAMK2B
  • CAMKB
  • CAM2
  • MGC29528
  • CAMK2
Protein TargetCaMKIIβ
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyCAMK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q13554 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
SIZE: 664 amino acids; 72727 Da
SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 (By similarity). Interacts with MPDZ.
TISSUE SPECIFICITY: Widely expressed. Expressed in adult and fetal brain. Expression islightly lower in fetal brain.
SIMILARITY: SwissProt: Q13554 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
Molecular Weight39.6kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of 250μM ZIPtide (Catalog # 12-545)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C from date of shipment
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-718) and in bulk (cat#14-718-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-718M 04053252441561

Documentation

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Alternative Packsize

Número de referencia Descripción
14-718 CaM Kinase IIβ Protein, active, 10 µg

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Categorías

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases