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14-917M CLK4 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human CLK4, amino acids 128-end, for use in Kinase Assays.

CLK4 Protein, active, 250 µg: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
14-917M
250 µg  Also available in 10μg size as catalog # 14-917 and in bulk as catalog # 14-917-K.
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue Number14-917M
Trade Name
  • Upstate
DescriptionCLK4 Protein, active, 250 µg
OverviewCLK4 protein belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.
References
Product Information
Presentation50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, human CLK4, amino acids 128-end, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceN-terminal 6His-tagged, recombinant, human CLK4 amino acids 128-end expressed by baculovirus in Sf21 insect cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Gene Symbol
  • CLK4
Protein TargetCLK4
Purification MethodPurified using immobilized metal affinity chromatography.
Target Sub-FamilyCMGC
UniProt Number
Molecular Weight46 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of peptide YRRAAVPPSPSLSRHSSPHQS(p)EDEEE.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10μg size as catalog # 14-917 and in bulk as catalog # 14-917-K.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
14-917M 04053252832123

Productos y aplicaciones relacionados

Alternative Packsize

Número de referencia Descripción
14-917 CLK4 Protein, active, 10 µg

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Categorías

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases