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SCT062 BioTracker Cys Hcy GSH Triple Live Cell Dye

Live cell imaging dye to simultaneously report for cellular levels of Glutathione (GSH), Cysteine (Cys) and Homocysteine (Hcy) which are inter-related and implicated in several diseases.

SCT062
1 mg  
Purchase on Sigma-Aldrich

Descripción

Replacement Information
Description
Catalogue NumberSCT062
DescriptionBioTracker Cys Hcy GSH Triple Live Cell Dye
OverviewBiothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) play crucial and ubiquitous roles in biological systems as endogenous species. GSH is a vital antioxidant and the most abundant intracellular biothiol. Substandard levels of GSH concentration are closely related to oxidative stress and several diseases. Cys is a building block for protein synthesis; cys is positioned in many active sites of proteins due to the reactivity of its sulfhydryl group. Abnormal levels of Cys may play an important part in various symptoms and diseases. The role of Hcy in diseases remains a highly contentious topic and abnormal total Hcy concentrations are believed to cause cognitive impairment in the elderly.

The BioTracker Cys Hcy GSH Cys triple live cell dye is a novel fluorescent probe with four binding sites, which can simultaneously and selectively detect Cys, Hcy, and GSH in three different emission channels. This probe can be used simultaneously monitor endogenous Cys and GSH and exogeneous Cys, Hcy, and GSH through multicolor imaging.

Spectral Properties
Excitation: 360 nm (Cys), 480 nm (Hcy) and 400 nm (GSH)
Emissions: 457 nm (Blue, Cys), 559 nm (Red, Hcy) and 529 nm (Green, GSH)

References
Yin G et al. A Multi-signal Fluorescent Probe with Multiple Binding Sites for Simultaneous Sensing of Cysteine, Homocysteine, and Glutathione. Angew Chem Int Ed. 2018, 57, 4991-4994.
Alternate Names
  • Live cell imaging probe
References
Product Information
Detection methodFluorescence
PresentationLyophilized
Applications
ApplicationLive cell imaging dye to simultaneously report for cellular levels of Glutathione (GSH), Cysteine (Cys) and Homocysteine (Hcy) which are inter-related and implicated in several diseases.
Key Applications
  • Cell Based Assays
Application NotesLive cell fluorescent imaging
Biological Information
ConcentrationPlease refer to lot specific datasheet.
Molecular Weight435.93 g/mol
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 435.93 g/mol
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore BioTracker Cys Hcy GSH Triple Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
SCT062 04054839008429