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189513 Autotaxin Inhibitor IV, HA155 - CAS 1312201-00-5 - Calbiochem

The Autotaxin Inhibitor IV, HA155 controls the biological activity of Autotaxin. This small molecule/inhibitor is primarily used for Cell Structure applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Atx Inhibitor IV, HA155, (Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid

189513
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
1312201-00-5C₂₄H₁₉BFNO₅S

Products

Número de referenciaEmbalaje Cant./Env.
189513-10MG Frasco de vidrio 10 mg
Description
OverviewA ~5-fold more potent (IC50 = 5.7 nM) para-isomer boronate analog of Autotaxin Inhibitor II, HA130 (Cat. No. 189511) that efficiently blocks thrombin-stimulated lysophosphatidic acid secretion in platelets and in mammalian cells.
Catalogue Number189513
Brand Family Calbiochem®
SynonymsAtx Inhibitor IV, HA155, (Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid
References
ReferencesFulkerson, Z., et al. 2011. J. Biol. Chem. 286, 34654.
Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol. 18, 198.
Albers, H.M.H.G., et al. 2011. J. Med. Chem. 54, 4619.
Albers, H.M.H.G., et al. 2010. J. Med. Chem. 53, 4958.
Product Information
CAS number1312201-00-5
FormYellow powder
Hill FormulaC₂₄H₁₉BFNO₅S
Chemical formulaC₂₄H₁₉BFNO₅S
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
189513-10MG 04055977221893

Documentation

Autotaxin Inhibitor IV, HA155 - CAS 1312201-00-5 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Referencias bibliográficas

Visión general referencias
Fulkerson, Z., et al. 2011. J. Biol. Chem. 286, 34654.
Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol. 18, 198.
Albers, H.M.H.G., et al. 2011. J. Med. Chem. 54, 4619.
Albers, H.M.H.G., et al. 2010. J. Med. Chem. 53, 4958.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-November-2012 JSW
SynonymsAtx Inhibitor IV, HA155, (Z)-4-((4-((3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden)-methyl)phenoxy)methyl)benzeneboronic acid
DescriptionA ~5-fold more potent (IC50 = 5.7 nM) para-isomer boronate analog of Autotaxin Inhibitor II, HA130 (Cat. No. 189511) that efficiently blocks thrombin-stimulated lysophosphatidic acid secretion in platelets and in mammalian cells.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1312201-00-5
Chemical formulaC₂₄H₁₉BFNO₅S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFulkerson, Z., et al. 2011. J. Biol. Chem. 286, 34654.
Hausmann, J., et al. 2011. Nat. Struct. Mol. Biol. 18, 198.
Albers, H.M.H.G., et al. 2011. J. Med. Chem. 54, 4619.
Albers, H.M.H.G., et al. 2010. J. Med. Chem. 53, 4958.