178494 Sigma-AldrichApoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem
The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications. Less<<Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Sinónimos: NS3694
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Descripción
Tabla espec. clave
| CAS # | Empirical Formula |
|---|---|
| 426834-38-0 | C₁₅H₁₀ClF₃N₂O₃ |
Products
| Número de referencia | Embalaje | Cant./Env. | |
|---|---|---|---|
| 178494-10MG | Ampolla de plást. | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases. |
| Catalogue Number | 178494 |
| Brand Family | Calbiochem® |
| Synonyms | NS3694 |
| References | |
|---|---|
| References | Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829. |
| Product Information | |
|---|---|
| CAS number | 426834-38-0 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₁₅H₁₀ClF₃N₂O₃ |
| Chemical formula | C₁₅H₁₀ClF₃N₂O₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Apoptosome complex formation |
| Primary Target IC<sub>50</sub> | 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Global Trade Item Number | |
|---|---|
| Número de referencia | GTIN |
| 178494-10MG | 04055977204803 |