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178488 Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem

The Apoptosis Inhibitor, also referenced under CAS 54135-60-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: M50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)

Primary Target: apoptosis induction
178488
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
54135-60-3C₁₃H₁₆O₄

Products

Número de referenciaEmbalaje Cant./Env.
178488-10MG Ampolla de plást. 10 mg
Description
OverviewA cell-permeable inhibitor of apoptosis induction (IC50 = 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells). Effects attributable to the inhibition of caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
Catalogue Number178488
Brand Family Calbiochem®
SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
References
ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.
Product Information
CAS number54135-60-3
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₃H₁₆O₄
Chemical formulaC₁₃H₁₆O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetapoptosis induction
Primary Target IC<sub>50</sub>67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
178488-10MG 04055977204780

Documentation

Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem Certificados de análisis

CargoNúmero de lote
178488

Referencias bibliográficas

Visión general referencias
Tsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-July-2009 RFH
SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
DescriptionA cell-permeable, bis(cyclohexane-1,3-diketone) that is shown to inhibit apoptosis induction in FasL-stimulated WC8 cells (IC50 = 67 µg/ml) and etoposide-stimulated U937 cells (IC50 = 130 µg/ml). The anti-apoptotic effects have been shown to be attributable to inhibition of caspase-3 activation (IC50 = 334 nM), however it does not exhibit any direct inhibition of caspase-3 enzymatic activity. Shown to inhibit the elevation of the liver enzymes, alanine aminotransferase and aspartate aminotransferase, in a murine model of anti-Fas-induced hepatitis. Topical application has been shown to reduce chemotherapy-induced alopecia (hair loss) in newborn rats.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number54135-60-3
Chemical formulaC₁₃H₁₆O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from moisture
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.