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178278 Apigenin - CAS 520-36-5 - Calbiochem

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM).

Apigenin - CAS 520-36-5 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4ʹ,5,7-Trihydroxyflavone

Primary Target: MAP kinase
178278
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
520-36-5C₁₅H₁₀O₅

Products

Número de referenciaEmbalaje Cant./Env.
178278-5MG Ampolla de plást. 5 mg
Description
OverviewInduces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation.
Catalogue Number178278
Brand Family Calbiochem®
Synonyms4ʹ,5,7-Trihydroxyflavone
References
ReferencesKuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767.
Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
Kuo, M.L., et al. 1994. Cancer Lett. 87, 91.
Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.
Product Information
CAS number520-36-5
ATP CompetitiveN
FormYellow crystalline solid
Hill FormulaC₁₅H₁₀O₅
Chemical formulaC₁₅H₁₀O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMAP kinase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLK9276000
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 36-26

Wear suitable protective clothing.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
178278-5MG 04055977222425

Documentation

Apigenin - CAS 520-36-5 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Apigenin - CAS 520-36-5 - Calbiochem Certificados de análisis

CargoNúmero de lote
178278

Referencias bibliográficas

Visión general referencias
Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767.
Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
Kuo, M.L., et al. 1994. Cancer Lett. 87, 91.
Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-March-2009 RFH
Synonyms4ʹ,5,7-Trihydroxyflavone
DescriptionA plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G2/M arrest and to induce morphological differentiation.
FormYellow crystalline solid
CAS number520-36-5
RTECSLK9276000
Chemical formulaC₁₅H₁₀O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or hot Ethanol (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.
Toxicity Irritant
Merck USA index14, 730
ReferencesKuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767.
Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
Kuo, M.L., et al. 1994. Cancer Lett. 87, 91.
Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.