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178276 Apicidin, Fusarium sp. - Calbiochem

A potent, cell-permeable inhibitor of histone deacetylase (IC₅₀= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties.

Apicidin, Fusarium sp. - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI

Primary Target: Histone deacetylase
178276
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₃₄H₄₉N₅O₆

Products

Número de referenciaEmbalaje Cant./Env.
178276-1MG Tambor de alum 1 mg
178276-5MG Tambor de alum 5 mg
Description
OverviewA potent, cell-permeable inhibitor of histone deacetylase (IC50= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50= 50-100 nM) and induces the transcriptional activation of p21 (WAF1). Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2.
Catalogue Number178276
Brand Family Calbiochem®
Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
References
ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₄H₄₉N₅O₆
Chemical formulaC₃₄H₄₉N₅O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHistone deacetylase
Primary Target IC<sub>50</sub>700 pM for parasitic histone deactetylase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
178276-1MG 04055977222401
178276-5MG 04055977222418

Documentation

Apicidin, Fusarium sp. - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Apicidin, Fusarium sp. - Calbiochem Certificados de análisis

CargoNúmero de lote
178276

Referencias bibliográficas

Visión general referencias
Colletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.

Licencias necesarias e Información técnica

Cargo
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-February-2019 JSW
Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
DescriptionA potent, cell-permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deactetylase) that also exhibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2 in a reversible manner.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₄H₄₉N₅O₆
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Highly Toxic
ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.