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09-466 Anti-phospho-CrkL (Tyr207) Antibody

Detect phospho-CrkL (Tyr207) using this Anti-phospho-CrkL (Tyr207) Antibody validated for use in WB.

Anti-phospho-CrkL (Tyr207) Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: v-crk avian sarcoma virus CT10 oncogene homolog-like, v-crk sarcoma virus CT10 oncogene homolog (avian)-like, Crk Like UniProt Number: P46109
09-466
100 µL  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, R, MWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number09-466
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-phospho-CrkL (Tyr207) Antibody
Background InformationCRKL belongs to a family of adaptor proteins containing SH2/SH3 domains that couple to effector proteins including p130CAS, SOS, Abl, and Arg. CRKL plays a role in the mediation of Integrin- and Rac-dependent cell migration and in Ras-dependent activation of JNK. The protein is also involved in T-cell activation. Phosphorylation of CrkL on Tyr207 is known to be correlated with its inhibition.
References
Product Information
FormatAffinity Purified
Control
  • K562
PresentationPurified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol.
Quality LevelMQ100
Applications
ApplicationDetect phospho-CrkL (Tyr207) using this Anti-phospho-CrkL (Tyr207) Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH synthetic peptide including and encompassing Tyr 207 of human CrkL.
HostRabbit
SpecificityRecognizes CrkL only when phosphorylated on Tyr207.
Species Reactivity
  • Human
  • Rat
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryNP_005198.1
Gene Symbol
  • v-crk avian sarcoma virus CT10 oncogene homolog-like
  • v-crk sarcoma virus CT10 oncogene homolog (avian)-like
  • Crk Like
Modifications
  • Phosphorylation
UniProt Number
UniProt SummaryFUNCTION: May mediate the transduction of intracellular signals.
SIZE: 303 amino acids; 33777 Da
SUBUNIT STRUCTURE:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.
SIMILARITY: Contains 1 SH2 domain.Contains 2 SH3 domains.
Molecular Weight39 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by western blot on K563 cell lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
09-466 04053252325779