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07-261 Anti-mGluR2 Antibody

Anti-mGluR2 Antibody is an antibody against mGluR2 for use in WB.

Anti-mGluR2 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors, Neurodegenerative Diseases Gene Symbol: GRM2, GPRC1B, MGLUR2, GLUR2, mGlu2, mGluR2 UniProt Number: Q14416
07-261
200 µg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
RWBRbPurifiedPolyclonal Antibody
Description
Catalogue Number07-261
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-mGluR2 Antibody
References
Product Information
FormatPurified
Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
ApplicationAnti-mGluR2 Antibody is an antibody against mGluR2 for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogenpeptide (RAPTSRFGSAAPRASANGC) corresponding to amino acids 829-845 of rat mGluR2
HostRabbit
SpecificitymGLUR2
IsotypeIgG
Species Reactivity
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Gene Symbol
  • GRM2
  • GPRC1B
  • MGLUR2
  • GLUR2
  • mGlu2
  • mGluR2
Purification MethodProtein A chromatography
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q14416 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
SIZE: 872 amino acids; 95568 Da
SUBUNIT: Interacts with GRASP (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed in different regions of the adult brain as well as in fetal brain.
SIMILARITY: SwissProt: Q14416 ## Belongs to the G-protein coupled receptor 3 family.
Molecular Weight105kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by immunoblot on Rat Brain Microsomes
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size200 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
07-261 04053252589195