Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

MABC582 Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1

Detect BIRC3 using this mouse monoclonal Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1, Cat. No. MABC582, validated for use in Western Blotting.

Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1 : Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: BIRC3, API2, IAP1, MIHC, RNF49 UniProt Number: Q13489
MABC582
100 μg  
Purchase on Sigma-Aldrich

Ofertas especiales

Descripción

Replacement Information

Ofertas especiales

100% Performance Guaranteed

Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC582
DescriptionAnti-hIAP-1/BIRC3 Antibody, clone 11D12.1
Alternate Names
  • Baculoviral IAP repeat-containing protein 3
  • Apoptosis inhibitor 2
  • API2
  • C-IAP2
  • IAP homolog C
  • Inhibitor of apoptosis protein 1
  • IAP-1
  • hIAP-1
  • hIAP1
  • RING finger protein 49
  • TNFR2-TRAF-signaling complex protein 1
  • hIAP-1/BIRC3
Background InformationBaculoviral IAP repeat-containing protein 3 (UniProt Q13489; also known as API2, Apoptosis inhibitor 2, Baculoviral IAP repeat-containing 3, c-IAP2, hIAP-1, hIAP1, IAP homolog C, IAP-1, Inhibitor of apoptosis protein 1, Mammalian IAP homolog C, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1) is encoded by the BIRC3 (also known as API2, AIP1, IAP1, HAIP1, HIAP1, MALT2, MIHC, RNF49) gene (Gene ID 330) in human. hIAP-1 (c-IAP2) belongs to the inhibitor of apoptosis (IAP) family of proteins characterized by the presence of at least one baculoviral IAP repeat (BIR) domain. hIAP-1 (c-IAP2 contains three BIR (BIR1/2/3) domains, followed by an UBA (ubiquitin-associated), a CARD (caspase activation and recruitment domain), and a RING (really interesting new gene) domain. The BIR domains mediate hIAP-1 interaction with various binding partners, such as caspases, other IAP family members, and receptor-associated complexes. The RING domain and its associated E3 ligase mediates not only the ubiqutination of substrate proteins, such as caspase-3, caspase-7, SMAC/DIABLO, but also self-ubiquitylation. The UBA domain enables hIAP-1 to engage protein complexes containing poly-ubiquitylated protein(s).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect BIRC3 using this mouse monoclonal Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1, Cat. No. MABC582, validated for use in Western Blotting.
Key Applications
  • Western Blotting
Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected hIAP-1/BIRC3 in 10 µg of TF-1, Jurkat, and Molt-4 cell lysate.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the BIR 1/2 of human hIAP-1/BIRC3.
Clone11D12.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • BIRC3
  • API2
  • IAP1
  • MIHC
  • RNF49
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~60 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected hIAP-1/BIRC3 in 10 µg of K562 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
MABC582 04055977177046

Documentation

Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1 Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1 Certificados de análisis

CargoNúmero de lote
Anti-hIAP-1/BIRC3, clone 11D12.1 -Q2583334 Q2583334

Licencias necesarias e Información técnica

Cargo
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.