Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

ABE361 Anti-acetyl-Histone H4 (Lys91) Antibody

Anti-acetyl-Histone H4 is an antibody against acetyl-Histone H4 for use in WB & Dot Blot.

Anti-acetyl-Histone H4 (Lys91) Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histones Gene Symbol: HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 UniProt Number: P62805
ABE361
100 µg  
Purchase on Sigma-Aldrich

Ofertas especiales

Descripción

Replacement Information

Ofertas especiales

100% Performance Guaranteed

Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, DBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE361
DescriptionAnti-acetyl-Histone H4 (Lys91) Antibody
Alternate Names
  • Histone H4
Background InformationHistones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine (K) residues by the family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which typically destabilizes chromatin structure and provide chromatin remodeling and transcriptional complexes with access to DNA, potentially resulting in increased gene transcription. Recent studies have suggested that acetylation of histone H4 lysine 91 facilitates the interaction of H3/H4 tetramers with H2A/H2B dimers, which is required for chromatin assembly.
References
Product Information
FormatAffinity Purified
Control
  • Untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H4
PresentationPurified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-acetyl-Histone H4 is an antibody against acetyl-Histone H4 for use in WB & Dot Blot.
Key Applications
  • Western Blotting
  • Dot Blot
Application NotesDot Blot Analysis: A representative lot detected acetylated Histone H4 (Lys91) in an AbSurance™ Histone H2A, H2B, H4 Antibody Specificity Array (Cat. No. 16-665).
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human Histone H4 acetylated at Lys91.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes Histone H4 acetylated at Lys91.
Species Reactivity
  • Human
Species Reactivity NoteDemonstrated to react with Human. Expected to react with most mammals due to conserved homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • HIST1H4A
  • H4/A
  • H4FA
  • HIST1H4B
  • H4/I
  • H4FI
  • HIST1H4C
  • H4/G
  • H4FG
  • HIST1H4D
  • H4/B
  • H4FB
  • HIST1H4E
  • H4/J
  • H4FJ
  • HIST1H4F
  • H4/C
  • H4FC
  • HIST1H4H
  • H4/H
  • H4FH
  • HIST1H4I
  • H4/M
  • H4FM
  • HIST1H4J
  • H4/E
  • H4FE
  • HIST1H4K
  • H4/D
  • H4FD
  • HIST1H4L
  • H4/K
  • H4FK
  • HIST2H4A
  • H4/N
  • H4F2
  • H4FN
  • HIST2H4
  • HIST2H4B
  • H4/O
  • H4FO
  • HIST4H4
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~13 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H4.

Western Blot Analysis: A 1:2,000 dilution from a representative lot detected acetylated Histone H4 (Lys91) in 10 µg of sodium butyrate treated HeLa acid extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
ABE361 04053252443749