Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

MAB318-AF555 Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 555 Conjugate

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers Gene Symbol: TH, TYH, DYT14, DYT5b UniProt Number: P07101
MAB318-AF555
100 µL  
Purchase on Sigma-Aldrich

Ofertas especiales

Descripción

Ofertas especiales

100% Performance Guaranteed

Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
Zebrafish, Ch, Fg, H, M, R, Vo, MkICCMAlexaFluor®555Monoclonal Antibody
Description
Catalogue NumberMAB318-AF555
DescriptionAnti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 555 Conjugate
Alternate Names
  • Tyrosine 3-monooxygenase
  • Dystonia 14
  • Tyrosine 3-hydroxylase
  • TH
Background InformationTyrosine 3-monooxygenase (EC 1.14.16.2; UniProt P07101; also known as Dystonia 14, TH, Tyrosine 3-hydroxylase) is encoded by the TH (also known as DYT14, DYT5b, TYH) gene (Gene ID 7054) in human. Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of dopamine and norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. TH enzymatic activity requires ferrous ions as cofactor and is believed to be regulated by phosphorylation. Six isoforms of human TH exist as a result of alternative splicing (UniProt P07101-1 through P07101-6).
Product Information
FormatAlexaFluor®555
PresentationPurified mouse monoclonal IgG1κ antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality LevelMQ100
Applications
Key Applications
  • Immunocytochemistry
Application NotesThe unconjugated antibody (Cat. No. MAB318) is shown to be suitable also for Western blotting, immunohistochemistry, and immunoprecipitation applications.
Biological Information
ImmunogenTyrosine Hydroxylase purified from PC12 cells.
EpitopeOn the outside of the regulatory N-terminus of tyrosine hydroxylase.
CloneLNC1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityRecognizes an epitope on the outside of the regulatory N-terminus. The unconjugated antibody (Cat. No. MAB318) recognizes a protein of approximately 59-61 kDa by Western blotting. The unconjugated antibody does not react with the following by Western blotting: dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase or phenethanolamine-N-methyl transferase (PNMT).
IsotypeIgG1κ
Species Reactivity
  • Zebrafish
  • Chicken
  • Frog
  • Human
  • Mouse
  • Rat
  • Vole
  • Monkey
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • TH
  • TYH
  • DYT14
  • DYT5b
Purification MethodProtein A Purfied
UniProt Number
Molecular Weight~59-63 kDa observed.
Product Usage Statements
Quality AssuranceEvaluated by Immunocytochemistry in rat cortical neurons.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Tyrosine Hydroxylase in rat cortical neurons.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Global Trade Item Number
Número de referencia GTIN
MAB318-AF555 04055977311969