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AB15624 Anti-Tbx1 Antibody

Anti-Tbx1 Antibody is a Rabbit Polyclonal Antibody for detection of Tbx1 also known as T-box 1 & has been validated in WB.

Anti-Tbx1 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience, Neuronal & Glial Markers Gene Symbol: TBX1, CTHM, VCFS, brachyury, TGA, TBX1C, DGS, DORV, CAFS, DGCR UniProt Number: O43435
AB15624
100 µg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB15624
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Tbx1 Antibody
Alternate Names
  • T-box 1
Background InformationThe T-box 1 protein appears to be necessary for the normal development of large arteries that carry blood out of the heart, muscles and bones of the face and neck, and glands such as the thymus and parathyroid. Although the T-box 1 protein acts as a transcription factor, it is not yet known which genes are regulated by the protein.
References
Product Information
FormatPurified
PresentationLiquid in PBS with 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Tbx1 Antibody is a Rabbit Polyclonal Antibody for detection of Tbx1 also known as T-box 1 & has been validated in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenSynthetic peptide from human Tbx1.
HostRabbit
SpecificityTbx1 (T-box 1).
Species Reactivity
  • Human
Species Reactivity NoteHuman. Other species have not been tested. The immunogen sequence has 76% homology with mouse.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene Symbol
  • TBX1
  • CTHM
  • VCFS
  • brachyury
  • TGA
  • TBX1C
  • DGS
  • DORV
  • CAFS
  • DGCR
Purification MethodImmunoAffinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O43435 # Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity).
SIZE: 398 amino acids; 43133 Da
SUBCELLULAR LOCATION: Nucleus (Potential).
DISEASE: SwissProt: O43435 # Haploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) [MIM:188400, 192430]. DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defects, cleft palate or velar insufficiency, facial dysmorpholgy and learning difficulties. It is now accepted that these two syndromes represent two forms of clinical expression of the same entity manifesting at different stages of life. & Defects in TBX1 are a cause of DiGeorge syndrome (DGS) [MIM:188400]. & Defects in TBX1 are a cause of velocardiofacial syndrome (VCFS) [MIM:192430]. & Defects in TBX1 are a cause of conotruncal heart malformations (CTHM) [MIM:217095]. CTHM consist of cardiac outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies.
SIMILARITY: SwissProt: O43435 ## Contains 1 T-box DNA-binding domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -20°C from date of shipment
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
AB15624 04053252585814