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ABN309 Anti-SAPAP1 Antibody

This SAPAP1 antibody is validated for use in WB & IHC for the detection of the SAPAP1 protein.

Anti-SAPAP1 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: DLGAP1, SAPAP1 UniProt Number: O14490
ABN309
100 µg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN309
DescriptionAnti-SAPAP1 Antibody
Alternate Names
  • SAP90
  • PSD-95-associated protein 1
  • Disks large-associated protein 1
  • DLGAP1
  • DAP-1
  • GKAP
Background InformationPSD-95/SAP90-binding protein 1 (SAPAP1) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP1 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP1 mRNA is targeted to cell bodies in a similar manner to SAPAP2 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies. SAPAP1 protein however, is targeted to the synapse and is not reliant on the synaptic localization of PSD-95 or the synaptic scaffolding molecule (S-SCAM).
References
Product Information
FormatAffinity Purified
Control
  • Human brain tissue lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis SAPAP1 antibody is validated for use in WB & IHC for the detection of the SAPAP1 protein.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SAPAP1 in human brain tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human SAPAP1.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityAt least three isoforms of SAPAP1 are known to exist. This SAPAP1 antibody will not cross-react with other SAPAP proteins.
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • DLGAP1
  • SAPAP1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~95 kDa observed. Uniprot describes 7 isoforms ranging between ~70 and ~109 kDa. An uncharacterized band may appear at ~58 kDa in some lysates. The calculated molecular weight is 109 kDa, however SAPAP1 has been shown as a ~95 kDa band in western blots. (Naisbitt, S., et al. (1997). 17(15):5687-5696.)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human brain tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected SAPAP1 in 10 µg of human brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
ABN309 04053252831065