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MABC698 Anti-PAWR, clone 3G9H7 Antibody

Detect PAWR using this Anti-PAWR, clone 3G9H7 Antibody validated for use in western blotting & IHC.

Anti-PAWR, clone 3G9H7 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PAWR, PAR4 UniProt Number: Q96IZ0
MABC698
100 µL  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCMAscitesMonoclonal Antibody
Description
Catalogue NumberMABC698
DescriptionAnti-PAWR, clone 3G9H7 Antibody
Alternate Names
  • PRKC apoptosis WT1 regulator protein
  • Prostate apoptosis response 4 protein
  • Par-4
  • PAWR
Background InformationPRKC apoptosis WT1 regulator protein, also known as Prostate apoptosis response 4 protein (Par-4), and encoded by the gene name PAWR or PAR4, is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. PAWR levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. PAWR is localized to the cytoplasm in the absence of apoptosis signal and in normal cells and localized to the nucleus in most cancer cells. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. PAWR is a WT1 interacting protein that also functions as a transcriptional repressor.
References
Product Information
FormatAscites
PresentationMouse monoclonal IgG1 ascitic fluid with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect PAWR using this Anti-PAWR, clone 3G9H7 Antibody validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:200-1:1,000 dilution from a representative lot detected PAWR in human brain and breast carcinoma tissues.
Biological Information
ImmunogenPurified recombinant fragment of human PAWR expressed in E. Coli
Clone3G9H7
HostMouse
IsotypeIgG1
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Gene Symbol
  • PAWR
  • PAR4
Purification MethodUnpurified
UniProt Number
Molecular Weight~43 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Full-length Trx-PAWR recombinant protein and HeLa cell lysate.

Western Blotting Analysis: A 1:500-1:2,000 dilution of this antibody detected PAWR in Full-length Trx-PAWR recombinant protein and HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
MABC698 04053252955266