Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

ABC934 Anti-Laminin Receptor Antibody

This Anti-Laminin Receptor Antibody is validated for use in Western Blotting, Immunocytochemistry for the detection of Laminin Receptor.

Anti-Laminin Receptor Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Adhesion (CAMs) Gene Symbol: RPSA, LAMBR, LAMR1 UniProt Number: P08865
ABC934
100 μg  
Purchase on Sigma-Aldrich

Ofertas especiales

Descripción

Replacement Information

Ofertas especiales

100% Performance Guaranteed

Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC934
DescriptionAnti-Laminin Receptor Antibody
Alternate Names
  • 40S ribosomal protein SA
  • 37 kDa laminin receptor precursor
  • 37/67 kDa laminin receptor
  • 37LRP
  • 67 kDa laminin receptor
  • 67LR
  • Colon carcinoma laminin-binding protein
  • Laminin-binding protein precursor p40
  • LamR
  • LBP/p40
  • LRP/LR
  • Laminin receptor 1
  • Multidrug resistance-associated protein MGr1-Ag
  • NEM/1CHD4
Background Information40S ribosomal protein SA (UniProt P08865; also known as 37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 37LRP, 67 kDa laminin receptor, 67LR, Colon carcinoma laminin-binding protein, Laminin-binding protein precursor p40, LamR, LBP/p40, LRP/LR, Laminin receptor 1, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4) is encoded by the RPSA (also known as LAMBR, LAMR1) gene (Gene ID 3921) in human. The The 37-kDa/67-kDa laminin receptor (LRP/LR) or ribosomal protein SA (RPSA) is a highly conserved protein that mediates diverse physiological and pathological functions on the cell surface, in the cytosol, in the 40S ribosomal complex, as well as in histone-, chromatin- and membrane-associated complexes in the nucleus. As a non-integrin cell surface glycoprotein, LRP/LR interacts with numerous extracellular matrix proteins in addition to its primary ligand, laminin-1, and mediates crucial cellular processes such as cell adhesion, migration, proliferation and differentiation, as well as facilitates the internalization of virus, infectious and non-infectious prion proteins. PRSA is produced as the 37 kDa precursor protein (37LRP), a proportion of 37LRP migrates to the cell surface and matures, via dimerization and/or posttranslational modification, into the 67 kDa high-affinity receptor (67LR) for laminin and other substrates including elastin and collagen. A 120 kDa form of the protein has also been described with yet unidenitified molecular characteristics in relationship to 37LRP. In addtion, 37LRP can heterodimerizes with galectin-3 (Gal-3), also known as the 31 kDa human laminin-binding protein (HLBP31). The 37LRP–Gal-3 heterodimer is distinct from the 67LR, which exists also in Neuro 2a (N2a) cells that do not express Gal-3.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Laminin Receptor Antibody is validated for use in Western Blotting, Immunocytochemistry for the detection of Laminin Receptor.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected laminin receptor in 10 µg of NIH/3T3 cell lysate.
Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected laminin receptor in A431, HeLa, HepG2, and NIH/3T3 cells.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to a sequence within the region between PPP1R16B-interacting and laminin-binding domains of human laminin receptor.
EpitopeRegion between PPP1R16B-interacting and laminin-binding domains.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis polyclonal antibody detects the 37, 67, and 120 kDa forms of laminin receptor by targeting a sequence in the region between PPP1R16B-interacting and laminin-binding domains.
Species Reactivity
  • Human
  • Mouse
Species Reactivity NoteHuman, Mouse. Predicted to react with Bovine, Porcine, Rat, Zebrafish, Xenopus based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • RPSA
  • LAMBR
  • LAMR1
Purification MethodAffinity purified.
UniProt Number
Molecular Weight~37/40 kDa observed. ~67 kDa and ~120 kDa forms were also observed upon longer exposure. Target bands appear larger than the calculated molecular weights of 32.73 kDa (Met1 removed) due to posttranslational modification (Butò, S., et al. (1998). J. Cell Biochem. 69(3):244-251).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected laminin receptor in 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
ABC934 04055977353457