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MAB1921-K Sigma-AldrichAnti-Laminin 1, clone 4E10 (1mL)

Anti-Laminin β1 Antibody, clone 4E10 detects level of Laminin β1 & has been published & validated for use in ELISA, IH, IP & WB.

Anti-Laminin 1, clone 4E10 (1mL): Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

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Description
Catalogue Number	MAB1921-K
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Laminin 1, clone 4E10 (1mL)
Overview	This product is intended for use by IVD manufacturers. Contact customer service for assistance: oem.reagents@emdmillipore.com
Alternate Names	Anti-Laminin

References

Product Information
Format	Ascites
Presentation	Liquid.
Quality Level	MQ300

Applications
Application	Anti-Laminin β1 Antibody, clone 4E10 detects level of Laminin β1 & has been published & validated for use in ELISA, IH, IP & WB.
Key Applications	ELISA Immunohistochemistry Immunoprecipitation Western Blotting
Application Notes	ELISA (50% maximal binding to human laminin): >1:1,600,000. Immunofluorescence Affinity chromatography Immunoprecipitation Immunoblotting Optimal working dilutions must be determined by end user.

Biological Information
Immunogen	Purified human laminin
Clone	4E10
Host	Mouse
Specificity	Reacts with the B1 portion of intact laminin and blocks the neurite stimulating activity of laminin.
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_002291.1
Entrez Gene Summary	Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
Gene Symbol	LAMB1 MGC142015 CLM
UniProt Number	P07942
UniProt Summary	FUNCTION: SwissProt: P07942 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. SIZE: 1786 amino acids; 198066 Da SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-1 is a subunit of laminin-1 (EHS laminin), laminin-2 (merosin), and laminin-6 (K-laminin). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. DOMAIN: SwissProt: P07942 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domains VI and IV are globular. SIMILARITY: Contains 13 laminin EGF-like domains. & Contains 1 laminin IV type B domain. & Contains 1 laminin N-terminal domain.

Physicochemical Information

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Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Packaging Information
Material Size	Bulk packaging. Please inquire.

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Número de referencia	GTIN
MAB1921-K	04053252660986

Documentation

Anti-Laminin 1, clone 4E10 (1mL) Ficha datos de seguridad (MSDS)

Título
Ficha técnica de seguridad del material (MSDS)

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