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MABS492 Anti-Lamin-B1 Antibody, clone 8F10.1

Anti-Lamin-B1 Antibody, clone 8F10.1 is an antibody against Lamin-B1 for use in Western Blotting, Immunohistochemistry (Paraffin).

Anti-Lamin-B1 Antibody, clone 8F10.1 : Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: LMNB1, LMN2, LMNB UniProt Number: P20700
MABS492
100 μg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS492
DescriptionAnti-Lamin-B1 Antibody, clone 8F10.1
Alternate Names
  • Lamin-B1
Background InformationLamin-B1 (UniProt P20700) is encoded by the LMNB1 (also known as ADLD, LMN2, LMNB) gene (Gene ID 4001) in human. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Two types of lamins, A and B, exist in vertebrates. Type B lamins, B1 and B2, are encoded by the LMNB1 and LMNB2 genes, respectively, and are present in all types of cells. Type A lamins are expressed only following gastrulation. Lamin A and C are the most common A-type lamins, they are both encoded by the LMNA gene and produced by alternative splicing.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Lamin-B1 Antibody, clone 8F10.1 is an antibody against Lamin-B1 for use in Western Blotting, Immunohistochemistry (Paraffin).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Lamin-B1 in human cerebellum, rat cerebellum, and human small instestine tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the Internal region of human Lamin-B1.
EpitopeInternal region
Clone8F10.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG2bκ
Species Reactivity
  • Human
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • LMNB1
  • LMN2
  • LMNB
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~66 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Lamin-B1 in 10 µg of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
MABS492 04055977297980