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ABN307 Anti-LGI1 Antibody

Detect the LGI1 protein using this Anti-LGI1 validated for use in WB & IHC.

Anti-LGI1 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: LGI1 UniProt Number: O95970
ABN307
100 µg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, R, HWB, IHCRbPurifiedPolyclonal Antibody
Description
Catalogue NumberABN307
DescriptionAnti-LGI1 Antibody
Alternate Names
  • Leucine-rich
  • glioma inactivated 1
  • epitempin
  • EPT
Background InformationThe leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are very similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms.
References
Product Information
FormatPurified
Control
  • Mouse brain tissue lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect the LGI1 protein using this Anti-LGI1 validated for use in WB & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesWestern Blot Analysis: 2 µg/mL from a representative lot detected LGI1 in 10 µg/mL of HEK293 cell lysate.

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected LGI1 in mouse cerebellum and rat cortex tissues.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human LGI1.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes only Isoform 1.
Species Reactivity
  • Mouse
  • Rat
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • LGI1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~64 kDa observed. Uniprot describes 3 isoforms at ~33 kDa, ~58 kDa, and ~64 kDa. An uncharacterized band may appear at ~45 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected LGI1 in 10 µg/mL of mouse brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
ABN307 04053252831041