Millipore Sigma Vibrant Logo
Atención: Nos hemos mudado. Los productos Merck Millipore ya no pueden adquirirse en MerckMillipore.comMás información

MAB1961H-I Anti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate

Anti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate is an antibody against Integrin αVβ5 for use in Flow Cytometry.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: ITGAV, MSK8, VNRA, VTNR, ITGB5 UniProt Number: P06756/P18084
MAB1961H-I
100 µL  
Purchase on Sigma-Aldrich

Ofertas especiales

Descripción

Replacement Information

Ofertas especiales

100% Performance Guaranteed

Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, Ch, HtFCMPhycoerythrinMonoclonal Antibody
Description
Catalogue NumberMAB1961H-I
DescriptionAnti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate
Alternate Names
  • Integrin alpha-V
  • CD51
  • Integrin alpha V
  • Vitronectin receptor subunit alpha
  • Integrin beta-5
Background InformationIntegrin alpha-V (UniProt P06756; CD51, Integrin alpha V, Vitronectin receptor subunit alpha) and Integrin beta-5 (UniProt P18084) are encoded by the ITGAV (MSK8, VNRA, VTNR; Gene ID 3685) and the ITGB5 (Gene ID 3693) gene, respectively, in human. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and a beta subunit associated in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence present in the extracellular matrix components, such as fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Integrin alphaVbeta5 is the primary mechanotransducer that mediates lung myofibroblast contraction-induced latent TGF-beta1 activation. Increased alphaVbeta5 expression is reported to be associated with myofibroblast differentiation. Integrin alphaVbeta5 is shown to interact with Thy-1 in an RLD-dependent manner. Thy-1 expression prevents fibroblast contraction-induced latent TGF-beta1 activation and lung myofibroblast differentiation.
References
Product Information
FormatPhycoerythrin
PresentationPurified mouse monoclonal IgG1 antibody in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate is an antibody against Integrin αVβ5 for use in Flow Cytometry.
Key Applications
  • Flow Cytometry
Application NotesThe unconjugated antibody (Cat. No. MAB1961 & MAB1961Z) is shown to be suitable also for Flow cytometry, Functional blocking, Immunocytochemistry, Immunohistochemistry, and Immunoprecipitation applications.
Biological Information
ImmunogenHuman UCLA P3 lung carcinoma cells (Weinacker, A., et al. (1994). J. Biol. Chem. 269(9):6940-6948).
EpitopeExtracellular region.
CloneP1F6
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone P1F6 recognizes αVβ5 without cross-reactivity toward αVβ3 (Weinacker, A., et al. (1994). J. Biol. Chem. 269(9):6940-6948).
IsotypeIgG1
Species Reactivity
  • Human
  • Chicken
  • Hamster
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ITGAV
  • MSK8
  • VNRA
  • VTNR
  • ITGB5
Purification MethodProtein A Purfied
UniProt Number
Molecular Weight112.7 kDa (alpha-V) and 86.34 kDa (beta-5) calculated. ~150 kDa (alpha-V) and 95 kDa (beta-5) reported (Weinacker, A., et al. (1994). J. Biol. Chem. 269(9):6940-6948) due to glycosylation.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Flow Cytometry in HT1080 cells.

Flow Cytometry Analysis: 1.0 µg of this antibody detected Integrin αVβ5 in HT1080 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
MAB1961H-I 04055977349603

Documentation

Anti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Anti-Integrin αVβ5 Antibody, clone P1F6, Phycoerythrin conjugate Certificados de análisis

CargoNúmero de lote
Anti-Integrin αVβ5, clone P1F6, Phycoerythrin conjugate - 3201463 3201463
Anti-Integrin αVβ5, clone P1F6, Phycoerythrin conjugate - 3517398 3517398
Anti-Integrin αVβ5, clone P1F6, Phycoerythrin conjugate - 3889539 3889539
Anti-Integrin αVβ5, clone P1F6, Phycoerythrin conjugate -Q2676864 Q2676864