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MAB1959-AF488 Anti-Integrin ß1 Antibody, clone P5D2, Alexa Fluor® 488 Conjugate

This Anti-Integrin ß1 Antibody, clone P5D2, Alexa Fluor® 488 Conjugate is validated for use in Flow Cytometry, Immunohistochemistry for the detection of Integrin ß1.

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Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: ITGB1, FNRB, MDF2, MSK12, VLA-BETA, VLAB UniProt Number: P05556
MAB1959-AF488
100 µL  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFC, IHCMAlexaFluor®488Monoclonal Antibody
Description
Catalogue NumberMAB1959-AF488
DescriptionAnti-Integrin ß1 Antibody, clone P5D2, Alexa Fluor® 488 Conjugate
Alternate Names
  • Integrin beta-1
  • CD29
  • Glycoprotein Iia
  • GPIIA
  • Integrin VLA-4 subunit beta
  • Very late activation protein
  • beta polypeptide
Background InformationIntegrin beta-1 (UniProt P05556; also known as CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide) is encoded by the ITGB1 (also known as FNRB, MDF2, MSK12, VLA-BETA, VLAB) gene (Gene ID 3688) in human. Integrin beta-1 is a 130 kDa transmembrane glycoprotein that interact with various integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptor complexes that bind to specific extracellular matrix proteins. Integrin receptors regulate a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor growth and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to the activation of signal transduction pathways and regulation of gene expression.
References
Product Information
FormatAlexaFluor®488
PresentationPurified mouse monoclonal IgG2bκ antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Integrin ß1 Antibody, clone P5D2, Alexa Fluor® 488 Conjugate is validated for use in Flow Cytometry, Immunohistochemistry for the detection of Integrin ß1.
Key Applications
  • Flow Cytometry
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Integrin ß1 in human small intestine and rat testis tissues.
Flow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected Integrin ß1 in 1X10E6 A431 cells.
The unconjugated antibody (Cat. No. MAB1959) is shown to be suitable also for functional assay, ELISA, , flow cytometry, immunocytochemistry, immunohistochemistry, and immunoprecipitation applications.
Biological Information
ImmunogenHuman keratinocytes derived from skin.
EpitopeExtracellular domain.
CloneP5D2
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityReacts with Integrin beta-1.
IsotypeIgG2bκ
Species Reactivity
  • Human
Species Reactivity NoteHuman. Mouse. Rat.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ITGB1
  • FNRB
  • MDF2
  • MSK12
  • VLA-BETA
  • VLAB
Purification MethodProtein A Purfied
UniProt Number
Molecular Weight~88 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in mouse cerebellum tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Integrin ß1 in mouse cerebellum tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
MAB1959-AF488 04055977314755