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ABE1384 Anti-Histone H2B type 2-E (H2be) Antibody

Anti-Histone H2B type 2-E (H2be) Antibody is an antibody against Histone H2B type 2-E for use in Western Blotting, Dot Blot.

Anti-Histone H2B type 2-E (H2be) Antibody : Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histones Gene Symbol: Hist2h2be UniProt Number: Q64524
ABE1384
50 μg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, R, MWB, DBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE1384
DescriptionAnti-Histone H2B type 2-E (H2be) Antibody
Alternate Names
  • Histone H2B type 2-E
  • H2b 613
  • H2be
  • Histone 2 H2be
Background InformationHistone H2B type 2-E (UniProt Q64524; also known as H2b 613, Histone 2 H2be) is encoded by the Hist2h2be gene (Gene ID 319190) in murine species. H2be is a replication-independent histone H2b variant expressed exclusively in olfactory chemosensory neurons. Levels of H2be are heterogeneous among olfactory neurons, but stereotyped according to the identity of the co-expressed olfactory receptor (OR). H2be is nearly undetectable in highly active neurons, but almost completely replaces H2b in inactive neurons. Changes in H2be expression affect olfactory function and OR representation in the adult olfactory epithelium. Genetic studies show that the deletion of H2be significantly extends the lifespan of neurons, whereas elevated H2be shortens their lifespan.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Histone H2B type 2-E (H2be) Antibody is an antibody against Histone H2B type 2-E for use in Western Blotting, Dot Blot.
Key Applications
  • Western Blotting
  • Dot Blot
Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected H2B type 2-E (H2be) in brain tissue lysates from wild-type, but not from Hist2h2be-knock mice (Courtesy of Professor C. David Allis, The Rockefeller University, New York).
Dot Blot Analysis: Specificity of this polyclonal antibody was confirmed using the antiserum prior to purification. The antiserum detected the H2B type 2-E (H2be) immunogen peptide, but not peptides derived from human/murine/rat H2b and H3 N-terminal sequences (Courtesy of Professor C. David Allis, The Rockefeller University, New York).
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the N-terminal sequence of mouse histone H2B type 2-E (H2be).
EpitopeN-terminal
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThe identity of an immunoreactive band of ~16 kDa detected by this polyclonal antibody using HeLa cell lysate has not been determined, but most likely corresponds to human histone H2B type 1-L (Histone H2B.c; Uniprot Q99880) whose N-terminal sequence (up to a.a. 39) is identical to that of murine histone H2B type 2-E.
Species Reactivity
  • Human
  • Rat
  • Mouse
Species Reactivity NoteHuman, Rat, Mouse. Broad species reactivity expected based on sequence similarity.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Hist2h2be
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~16 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected histone H2B type 2-E (H2be) in 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size50 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
ABE1384 04055977299946