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05-1587 Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2

Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2 is a Mouse Monoclonal Antibody for detection of FOXO3a/FKHRL1 also known as Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1 & has been validated in WB & IHC.

Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Apoptosis - Additional Gene Symbol: FOXO3, FKHRL1, FOXO3A UniProt Number: O43524
05-1587
100 µg  
Purchase on Sigma-Aldrich

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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue Number05-1587
Replaces04-1007
DescriptionAnti-FOXO3a/FKHRL1 Antibody, clone 15F7.2
Alternate Names
  • Forkhead box protein O3
  • AF6q21 protein
  • Forkhead in rhabdomyosarcoma-like 1
Background InformationForkhead box protein O3 (FOXO3a), or FKHRL1, is a ubiquitous transcription factor that triggers the expression of pro-apoptotic genes under conditions of oxidative stress. FOXO3a is regulated by the Akt kinase which phosphorylates FOXO3a on serine 253, 315, and on threonine 32 residues. Modified FOXO3a is recognized by the 14-3-3 proteins which export FOXO3a to the cytoplasm, and consequently terminates its transcriptional activity. FOXO3a may also be regulated by lysine methylation in neuronal cells.
References
Product Information
FormatPurified
Control
  • Rat liver tissue lysate.
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-FOXO3a/FKHRL1 Antibody, clone 15F7.2 is a Mouse Monoclonal Antibody for detection of FOXO3a/FKHRL1 also known as Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1 & has been validated in WB & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:300 dilution from a representative lot detected FOXO3a/FKHRL1 in human thyroid gland tissue and human breast cancer tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human FOX03a.
Clone15F7.2
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • FOXO3
  • FKHRL1
  • FOXO3A
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~71 kDa observed. An uncharacterized band may be observed at ~28 kDa in some tissue lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in rat liver tissue lysate.

Western Blot Analysis: 0.2 µg/mL of this antibody detected FOXO3a/FKHRL1 in 10 mg of rat liver tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
05-1587 04053252597756

Documentation

Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2 Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Anti-FOXO3a/FKHRL1 Antibody, clone 15F7.2 Certificados de análisis

CargoNúmero de lote
Anti-FOXO3a/FKHRL1, clone 15F7.2 - 2379498 2379498
Anti-FOXO3a/FKHRL1, clone 15F7.2 - 2276373 2276373
Anti-FOXO3a/FKHRL1, clone 15F7.2 - 2287779 2287779
Anti-FOXO3a/FKHRL1, clone 15F7.2 - 3152159 3152159
Anti-FOXO3a/FKHRL1, clone 15F7.2 - 3561575 3561575
Anti-FOXO3a/FKHRL1, clone 15F7.2 - Q2025110 Q2025110
Anti-FOXO3a/FKHRL1, clone 15F7.2 -2857487 2857487