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AB3582P Anti-Cyclic Nucleotide-Gated Channel 1 Antibody, CT

Anti-Cyclic Nucleotide-Gated Channel 1 Antibody, C-terminus detects level of Cyclic Nucleotide-Gated Channel 1 & has been published & validated for use in ELISA & WB.

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Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: CNGA1, CNCG, RCNCalpha, CNG-1, RCNC1, CNCG1, RCNCa, CNG1 UniProt Number: P29973
AB3582P
50 µg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, PoELISA, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB3582P
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Cyclic Nucleotide-Gated Channel 1 Antibody, CT
Alternate Names
  • CNG1
References
Product Information
FormatAffinity Purified
PresentationAffinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA.
Quality LevelMQ100
Applications
ApplicationAnti-Cyclic Nucleotide-Gated Channel 1 Antibody, C-terminus detects level of Cyclic Nucleotide-Gated Channel 1 & has been published & validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application NotesWestern blot: 1-10 g/mL using ECL.
ELISA: 0.5-1 g/mL using 1 g/mL control peptide per well.

Immunohistochemistry: not tested. It is recommended that the antibody be tried at 2-20 μg/mL on paraformaldehyde fixed tissue.

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenA 20 amino acid peptide sequence near the N-terminus of human CNG1 (Dhallan et al. 1992; Distler et al. 1994; Bonigk et al. 1993).
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes human Cyclic Nucleotide-Gated Channel 1 (CNG1). The immunogen shows no significant sequence homology with other CNG's.

SPECIES REACTIVITIES: The immunogen sequence is 100% conserved in porcine, 80% in bovine, 70% in canine and 57% in rat. Reactivity with other species has not been confirmed.
Species Reactivity
  • Human
  • Pig
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CNGA1
  • CNCG
  • RCNCalpha
  • CNG-1
  • RCNC1
  • CNCG1
  • RCNCa
  • CNG1
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P29973 # Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
SIZE: 686 amino acids; 79126 Da
SUBUNIT: Homotetramer or higher oligomer. Forms heterooligomeric complex with CNG4.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Rod cells in the retina.
DISEASE: SwissProt: P29973 # Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
SIMILARITY: SwissProt: P29973 ## Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. & Contains 1 cyclic nucleotide-binding domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
AB3582P 04053252280160