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AB5370P Anti-Capsaicin Receptor Antibody, CT

Anti-Capsaicin Receptor Antibody, C-terminus is an antibody against Capsaicin Receptor for use in IH.

Anti-Capsaicin Receptor Antibody, CT: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Neuroinflammation & Pain, Neurotransmitters & Receptors Gene Symbol: TRPV1, VR1, OTRPC1, DKFZp434K0220, TrpV1 UniProt Number: Q8NER1
AB5370P
20 µg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RIHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB5370P
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Capsaicin Receptor Antibody, CT
Alternate Names
  • Vanilloid Receptor 1
  • VR1
References
Product Information
FormatAffinity Purified
PresentationAffinity purified immunoglobulin. Lyophilized. Contains no preservative. Reconstitute with 20 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
Quality LevelMQ100
Applications
ApplicationAnti-Capsaicin Receptor Antibody, C-terminus is an antibody against Capsaicin Receptor for use in IH.
Key Applications
  • Immunohistochemistry
Application NotesImmunohistochemistry: 1-2 μg/mL.

The antibody reacts well with tissue from the rat dorsal root ganglia.

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenA 21 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein.
EpitopeC-terminus
HostRabbit
SpecificityCapsaicin Receptor (Vanilloid Receptor 1, VR1).
Species Reactivity
  • Human
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryCapsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
Gene Symbol
  • TRPV1
  • VR1
  • OTRPC1
  • DKFZp434K0220
  • TrpV1
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q8NER1 # Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
SIZE: 839 amino acids; 94938 Da
SUBUNIT: Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).DOMAIN:SwissProt: Q8NER1 The association domain (AD) is necessary for self- association (By similarity).
PTM: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity (By similarity).
SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. & Contains 3 ANK repeats.
MISCELLANEOUS: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
Packaging Information
Material Size20 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
AB5370P 04053252279058

Documentation

Anti-Capsaicin Receptor Antibody, CT Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Anti-Capsaicin Receptor Antibody, CT Certificados de análisis

CargoNúmero de lote
RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) - 3421950 3421950
RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 2937876
RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 2935539
RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 2967783
RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2048753 2048753
RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2110457 2110457
RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2281630 2281630
RABBIT ANTI-CAPSAICIN RECEPTOR -2639446 2639446

Referencias bibliográficas

Visión general referenciasAplicación EspeciePub Med ID
Expression and distribution of vannilloid receptor 1 (TRPV1) in the adult rat brain
Toth, A. et al.
Molecular Brain Research, 135:162-168 (2005)  2004

Immunoblotting (Western), Immunohistochemistry (Tissue)Rat15857679 15857679