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ABS453 Anti-CHD7 Antibody

Anti-CHD7 Antibody is a highly specific rabbit polyclonal antibody, that targets CHD7 & has been tested in western blotting & IHC.

Anti-CHD7 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: CHD7 UniProt Number: Q9P2D1
ABS453
100 µg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABS453
DescriptionAnti-CHD7 Antibody
Alternate Names
  • Chromodomain helicase DNA binding protein 7
  • CHD-7
  • IS3
  • KAL5
  • ATP-dependent helicase CHD7
Background InformationChromodomain-helicase-DNA-binding protein 7 (CHD7), also known as ATP-dependent helicase CHD7, belongs to a superfamily of proteins of the ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. CHD7 may play an important role in early embryonic development by affecting chromatin structure and gene expression. CHD7 interacts with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes. Defects in CHD7 are suggested to be the cause of CHARGE syndrome (CHARGES) and idiopathic scoliosis type 3 (IS3). Mutations in CHD7 may also result in hypogonadotropic hypogonadism (HH5). CHD7 is widely expressed in fetal and adult tissues.
References
Product Information
FormatAffinity Purified
Control
  • SK-N-SH cell lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-CHD7 Antibody is a highly specific rabbit polyclonal antibody, that targets CHD7 & has been tested in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: 5 µg/mL from a representative lot detected CHD7 in mouse brain tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human CHD7.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
  • Mouse
Antibody TypePolyclonal Antibody
Gene Symbol
  • CHD7
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~290 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~128 kDa and ~336 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in SK-N-SH cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected CHD7 in 15 µg of SK-N-SH cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
ABS453 04053252907036