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MABF384 Anti-CD127 (IL-7Ra) Antibody (mouse), clone A7R34

This Rat Monoclonal Antibody Anti-CD127 (IL-7Ra) (mouse), clone A7R34, Cat. No. MABF384 is validated for use in IP, IHC, Immunofluorescence and Flow Cytometry for the detection of CD127 (IL-7Ra).

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Research Category: Inflammation & Immunology Gene Symbol: Il17ra, Il17r UniProt Number: Q60943
MABF384
100 µg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
MIP, IHC, IF, FCRPurifiedMonoclonal Antibody
Description
Catalogue NumberMABF384
DescriptionAnti-CD127 (IL-7Ra) Antibody (mouse), clone A7R34
Alternate Names
  • Interleukin-17 receptor A
  • IL-17 receptor A
  • IL-17RA
  • CD217
Background InformationThe A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).
References
Product Information
FormatPurified
PresentationPurified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, pH 7.2, and up to 0.1% sodium azide”.
Quality LevelMQ100
Applications
ApplicationThis Rat Monoclonal Antibody Anti-CD127 (IL-7Ra) (mouse), clone A7R34, Cat. No. MABF384 is validated for use in IP, IHC, Immunofluorescence and Flow Cytometry for the detection of CD127 (IL-7Ra).
Key Applications
  • Immunoprecipitation
  • Immunohistochemistry
  • Immunofluorescence
  • Flow Cytometry
Biological Information
ImmunogenImmunogen information for this antibody is proprietary information.
CloneA7R34
Concentration0.5 mg/mL
HostRat
SpecificityM
IsotypeIgG2aκ
Species Reactivity
  • Mouse
Antibody TypeMonoclonal Antibody
Gene Symbol
  • Il17ra
  • Il17r
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsIt is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
MABF384 04053252959608

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Categorías

Life Science Research > Antibodies and Assays > Primary Antibodies