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MABF1502 Anti-CD11c (Mouse), redFluor™ 710, clone N418 Antibody

Anti-CD11c (Mouse), redFluor™ 710, clone N418 Antibody detects level of CD11c and has been published and validated for use in Flow Cytometry.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Itgax UniProt Number: Q9QXH4
MABF1502
100 μg  
Purchase on Sigma-Aldrich

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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
MFCAHmredFluor™ 710Monoclonal Antibody
Description
Catalogue NumberMABF1502
DescriptionAnti-CD11c (Mouse), redFluor™ 710, clone N418 Antibody
Alternate Names
  • Integrin alpha-X
  • CD11 antigen-like family member C
  • Leukocyte adhesion glycoprotein p150,95 alpha chain
  • Leukocyte adhesion receptor p150,95
  • CD11c
  • CD11c
Background InformationThe N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling throµgh ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).
Product Information
FormatredFluor™ 710
PresentationPurified Armenian Hamster monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Quality LevelMQ100
Applications
ApplicationAnti-CD11c (Mouse), redFluor™ 710, clone N418 Antibody detects level of CD11c and has been published and validated for use in Flow Cytometry.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenImmunogen information for this antibody is proprietary information.
CloneN418
ConcentrationPlease refer to lot specific datasheet.
HostArmenian Hamster
IsotypeIgG
Species Reactivity
  • Mouse
Antibody TypeMonoclonal Antibody
Gene Symbol
  • Itgax
Purification MethodPurified by size-exclusion chromatography
UniProt Number
Product Usage Statements
Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD11c in one million C57Bl/6 splenocytes.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Packaging Information
Material Size100 μg
Global Trade Item Number
Número de referencia GTIN
MABF1502 04055977292190