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MABT153 Anti-Aggrecan Antibody (full length), clone 4D7.1

This Anti-Aggrecan Antibody (full length), clone 4D7.1 is validated for use in Western Blotting for the detection of Aggrecan (full length).

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Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: ACAN, AGC1, CSPG1, MSK16 UniProt Number: P16112
MABT153
100 µg  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABT153
DescriptionAnti-Aggrecan Antibody (full length), clone 4D7.1
Alternate Names
  • Aggrecan core protein
  • Cartilage-specific proteoglycan core protein
  • CSPCP
  • Chondroitin sulfate proteoglycan core protein 1
  • Chondroitin sulfate proteoglycan 1
Background InformationAggrecan is an extracellular protein that is also known as Aggrecan core protein, Cartilage-specific proteoglycan core protein (CSPCP), Chondroitin sulfate proteoglycan core protein 1, and Chondroitin sulfate proteoglycan 1. Aggrecan is encoded by the gene ACAN/AGC1/CSPG1/MSK16. Aggrecan is a proteoglycan that is a major component of the extracellular matrix of cartilaginous tissues. The major function of Aggrecan is to resist compression in cartilage, thus providing protection for joint movement and against injury. Aggrecan binds various other ECM proteins via its large globular domains. Aggrecan can be cleaved into Aggrecan core protein 2, a C-terminal fragment component that decreases in cartilage as people age. Aggrecan is expressed in cartilage and is a massive (>2500 kDa) proteoglycan protein that has multiple isoforms. The appearance of Aggrecan fragments in the blood is a marker for various joint diseases.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Aggrecan Antibody (full length), clone 4D7.1 is validated for use in Western Blotting for the detection of Aggrecan (full length).
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human Aggrecan.
Clone4D7.1
Concentration1 mg/mL
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ACAN
  • AGC1
  • CSPG1
  • MSK16
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~270 kDa observed. The calculated molecular weight is 250 kDa. However, this protein is known to be highly glycosylated and may be observed at higher molecular weights.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human chondrocyte cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected Aggrecan (full length) in 10 µg of human chondrocyte cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
MABT153 04053252975646

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Categorías

Life Science Research > Antibodies and Assays > Primary Antibodies