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AB10328 Anti-1A1 Antibody

Detect 1A1 using this Anti-1A1 Antibody validated for use in WB.

Anti-1A1 Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Metabolism Research Sub-Category: Enzymes & Biochemistry Gene Symbol: AHH, AHRR, EC 1.14.14.1 , CP11, CYP1, CYPIA1 , P1-450, P450-P1, P450DX UniProt Number: P04798
AB10328
50 µL  
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Tabla espec. clave

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB10328
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-1A1 Antibody
Alternate Names
  • Cytochrome P450 1A1
Background InformationCYP1A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme’s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
References
Product Information
FormatSerum
PresentationRaw rabbit serum with 0.05% sodium azide.
Applications
ApplicationDetect 1A1 using this Anti-1A1 Antibody validated for use in WB.
Key Applications
  • Western Blotting
Application NotesSuggested dilutions:
Western Blot: 1:5000
Biological Information
ImmunogenRecombinant human 1A1
EpitopeAA 242 to 319
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Gene Symbol
  • AHH
  • AHRR
  • EC 1.14.14.1
  • CP11
  • CYP1
  • CYPIA1
  • P1-450
  • P450-P1
  • P450DX
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P04798# Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
SIZE: 512 amino acids; 58165 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt: P04798# Belongs to the cytochrome P450 family.
Molecular Weight58 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C for up to 12 months from date of receipt.
Packaging Information
Material Size50 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
AB10328 04053252584640