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176708 Angiostatin K1-3, Human, Recombinant, E. coli

Angiostatin K1-3 is a recombinant form expressed in E. coli as a single, non-glycosylated polypeptide chain of 259 amino acids. A specific inhibitor of endothelial cell growth and angiogenesis.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Ang K1-3, K1-3, rHuAng K1-3

176708
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Products

Número de referenciaEmbalaje Cant./Env.
176708-250UG Frasco de vidrio 250 μg
Description
OverviewRecombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
Catalogue Number176708
Brand Family Calbiochem®
SynonymsAng K1-3, K1-3, rHuAng K1-3
References
ReferencesCao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
O'Rieilly, M.S., et al. 1994. Cell 79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.
Product Information
FormLyophilized powder
FormulationLyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC and SDS-PAGE
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
176708-250UG 04055977222968

Documentation

Angiostatin K1-3, Human, Recombinant, E. coli Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Angiostatin K1-3, Human, Recombinant, E. coli Certificados de análisis

CargoNúmero de lote
176708

Referencias bibliográficas

Visión general referencias
Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
O'Rieilly, M.S., et al. 1994. Cell 79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-July-2010 RFH
SynonymsAng K1-3, K1-3, rHuAng K1-3
DescriptionRecombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50=70 nM) relative to kringles 1-4 (ED50=135 nm).
FormLyophilized powder
FormulationLyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.
Purity≥95% by HPLC and SDS-PAGE
SolubilityH2O or Aqueous Buffer Containing 0.1% BSA
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728.
Cao, E., et al. 1997. J. Biol. Chem. 272, 22924.
Sim, B.K., et al. 1997. Cancer Res. 57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651.
O'Rieilly, M.S., et al. 1994. Cell 79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104.
Forsgren, M., et al. 1987. FEBS Lett. 213, 254.
Malinowski, D.P., et al. 1984. Biochemistry 23, 4243.