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12-346 Acetyl-Histone H4 (Lys16) Peptide

Acetyl-Histone H4 (Lys16) Peptide primarily used in Histone Acetyltransferase Assays (HAT) and Western Blotting.

Acetyl-Histone H4 (Lys16) Peptide: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Key Applications: Histone Acetyltransferase Assay (HAT), Western Blotting UniProt Number: P62805 Entrez Gene Number: NM_003538.3
12-346
100 µg  
Purchase on Sigma-Aldrich

Descripción

Replacement Information

Tabla espec. clave

Key ApplicationsEntrez Gene NumberModificationsUni Prot Number
HAT, WBNM_003538.3 Acetylation P62805
Description
Catalogue Number12-346
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAcetyl-Histone H4 (Lys16) Peptide
References
Product Information
Presentationsterile deionized water
Quality LevelMQ100
Applications
ApplicationAcetyl-Histone H4 (Lys16) Peptide primarily used in Histone Acetyltransferase Assays (HAT) and Western Blotting.
Key Applications
  • Histone Acetyltransferase Assay (HAT)
  • Western Blotting
Biological Information
Entrez Gene Number
Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Gene Symbol
  • HIST1H4A
  • H4/J
  • HIST1H4F
  • HIST1H4L
  • H4FN
  • H4FA
  • H4FH
  • HIST1H4H
  • H4F2
  • H4FM
  • H4/A
  • H4FK
  • H4FG
  • HIST2H4
  • H4FB
  • H4/K
  • HIST1H4I
  • H4/N
  • HIST1H4B
  • H4FE
  • H4/M
  • H4/a
  • HIST1H4E
  • HIST4H4
  • HIST2H4A
  • H4FC
  • H4FI
  • H4/H
  • HIST1H4C
  • H4/G
  • HIST1H4K
  • H4FJ
  • H4FD
  • H4/I
  • H4/B
  • H4/D
  • H4/C
  • HIST1H4J
  • HIST1H4D
  • H4/E
Modifications
  • Acetylation
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 103 amino acids; 11367 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by Immunoblot Analysis. This peptide can be used as a standard for antibodies specific for acetylation of lysine 16 of histone H4.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
12-346 04053252278594

Documentation

Acetyl-Histone H4 (Lys16) Peptide Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Acetyl-Histone H4 (Lys16) Peptide Certificados de análisis

CargoNúmero de lote
Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) - 2435049 2435049
Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) 2962962
Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) 2930489
Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) 3111206
Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) - 2227359 2227359
Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) - 2301394 2301394
Acetyl-Histone H4 (Lys16) Peptide (substrate for HAT activity) -2505159 2505159
Acetyl-Histone H4 (Lys16) Peptide - 16453 16453
Acetyl-Histone H4 (Lys16) Peptide - 2032850 2032850
Acetyl-Histone H4 (Lys16) Peptide - 20552 20552
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Referencias bibliográficas

Visión general referenciasPub Med ID
The TAF(II)250 subunit of TFIID has histone acetyltransferase activity.
Mizzen, C A, et al.
Cell, 87: 1261-70 (1996)  1996

Mostrar resumen 		8980232 8980232

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Categorías

Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Control Histones