118490 Sigma-AldrichATIC Dimerization Inhibitor - CAS 1402453-15-9 - Calbiochem
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Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Sinónimos: AMPK Signaling Activator XI, Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor
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Descripción
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Products
| Número de referencia | Embalaje | Cant./Env. | |
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| 118490-10MG | Frasco de vidrio | 10 mg |
| Description | |
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| Overview | A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 240 nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040). |
| Catalogue Number | 118490 |
| Brand Family | Calbiochem® |
| Synonyms | AMPK Signaling Activator XI, Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor |
| References | |
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| References | Spurr, I.B., et al. 2012. ChemBioChem 13, 1628. |
| Product Information | |
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| CAS number | 1402453-15-9 |
| Form | White solid |
| Hill Formula | C₂₁H₃₃N₇O₅ |
| Chemical formula | C₂₁H₃₃N₇O₅ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | ATIC |
| Primary Target K<sub>i</sub> | 691 nM (Kd |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Ac-Arg-Ph(4-NO2)-NEt2 |
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| Toxicological Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Número de referencia | GTIN |
| 118490-10MG | 04055977224023 |
Documentation
ATIC Dimerization Inhibitor - CAS 1402453-15-9 - Calbiochem Ficha datos de seguridad (MSDS)
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ATIC Dimerization Inhibitor - CAS 1402453-15-9 - Calbiochem Certificados de análisis
| Cargo | Número de lote |
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| 118490 |
Referencias bibliográficas
| Visión general referencias |
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| Spurr, I.B., et al. 2012. ChemBioChem 13, 1628. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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