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548000 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt - CAS 5108-96-3 - Calbiochem

Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: APDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄

Primary Target: Induction of nitric oxide synthase activity in rat alveolar macrophages
548000
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
5108-96-3C₅H₁₂N₂S₂

Products

Número de referenciaEmbalaje Cant./Env.
548000-100MG Ampolla de plást. 100 mg
Description
OverviewCell permeable. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells. Inhibits NF-κB activation and HIV replication in lymphocytes.
Catalogue Number548000
Brand Family Calbiochem®
SynonymsAPDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄
References
ReferencesTsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667.
Pan, Z., et al. 1995. J. Biol. Chem. 270, 7787.
Bessho, R., et al. 1994. Biochem. Pharmacol. 48, 1883.
Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun. 191, 1301.
Schreck, R., et al. 1992. J. Exp. Med. 175, 1181.
Product Information
CAS number5108-96-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₅H₁₂N₂S₂
Chemical formulaC₅H₁₂N₂S₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInduction of nitric oxide synthase activity in rat alveolar macrophages
Purity≥98% by titration
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.



From Catalog:
Desc. Field- added "cell-permeable
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
548000-100MG 07790788051419

Documentation

1-Pyrrolidinecarbodithioic Acid, Ammonium Salt - CAS 5108-96-3 - Calbiochem Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

1-Pyrrolidinecarbodithioic Acid, Ammonium Salt - CAS 5108-96-3 - Calbiochem Certificados de análisis

CargoNúmero de lote
548000

Referencias bibliográficas

Visión general referencias
Tsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667.
Pan, Z., et al. 1995. J. Biol. Chem. 270, 7787.
Bessho, R., et al. 1994. Biochem. Pharmacol. 48, 1883.
Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun. 191, 1301.
Schreck, R., et al. 1992. J. Exp. Med. 175, 1181.

Folleto

Cargo
Caspases and other Apoptosis Related Tools Brochure
Pathways and Biomarkers of Oxidative Stress

Citas

Título
  • Teresa Sanchez Alcaraz, et al. 2004. Journal of Virology 78, 6180.
    		•
    Ficha técnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision09-September-2008 RFH
    SynonymsAPDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄
    DescriptionCell permeable. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells. Inhibits NF-κB activation and HIV replication in lymphocytes.
    FormWhite solid
    CAS number5108-96-3
    Chemical formulaC₅H₁₂N₂S₂
    Structure formulaStructure formula
    Purity≥98% by titration
    SolubilityH₂O (1 mg/ml)
    Storage +2°C to +8°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.



    From Catalog:
    Desc. Field- added "cell-permeable
    Toxicity Irritant
    ReferencesTsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667.
    Pan, Z., et al. 1995. J. Biol. Chem. 270, 7787.
    Bessho, R., et al. 1994. Biochem. Pharmacol. 48, 1883.
    Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun. 191, 1301.
    Schreck, R., et al. 1992. J. Exp. Med. 175, 1181.
    Citation
  • Teresa Sanchez Alcaraz, et al. 2004. Journal of Virology 78, 6180.
    		•