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149101 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.

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Sinónimos: ACPC

Primary Target: Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
149101
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Descripción

Tabla espec. clave

CAS #Empirical Formula
22059-21-8C₄H₇NO₂

Products

Número de referenciaEmbalaje Cant./Env.
149101-1GM Frasco de vidrio 1 gm
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149101-250MG Frasco de vidrio 250 mg
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Description
OverviewAn agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3H-glycine binding to rat forebrain membrane (IC50 = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC50 = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
Catalogue Number149101
Brand Family Calbiochem®
SynonymsACPC
References
ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
Zapata, A., et al. 1996. NeuroReport 7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.
Product Information
CAS number22059-21-8
ATP CompetitiveN
FormCrystalline solid
Hill FormulaC₄H₇NO₂
Chemical formulaC₄H₇NO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Application1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
Biological Information
Primary TargetGlycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
Primary Target IC<sub>50</sub>38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells
Purity≥ 98% by TLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSGZ1110000
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Global Trade Item Number
Número de referencia GTIN
149101-1GM 07790788059590
149101-250MG 04055977207521