Eshmuno® CPS Resin

The Salt Tolerant Cation
Exchange Resin

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For the purification of recombinant proteins at elevated
conductivity levels

Eshmuno® CPS resin combines high dynamic binding capacity and separation efficiency in downstream purification of recombinant protein feed streams at elevated salt concentrations. The demonstrated salt tolerance of Eshmuno® CPS resin enables direct loading of high conductivity feed streams (conductivity ≥10 mS/cm), reducing the need for dilution. Direct savings can be made on buffer, time and manufacturing footprint. Streamlined process steps, associated with efficient purification result in an overall improved productivity.

As a strong cation exchanger without hydrophobic groups, Eshmuno® CPS resin allows easy process development with straightforward binding and elution conditions and selection of process parameters.

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Eshmuno® CPS resin

Ordering Information

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Eshmuno® CPS resin provides:
Outstanding binding capacities at elevated conductivity levels (≥ 10 mS/cm) Excellent separation efficiencies at high protein loadings Ease of implementation and selection of process parameters through strong cation exchanger chemistry without hydrophobic groups Rigid base bead that enables higher flow rates and easier column packing

Outstanding binding capacities

Eshmuno® CPS resin provides significantly higher dynamic binding capacities for the model protein Chymotrypsinogen A at elevated conductivity levels compared to benchmark resins.


Determination of dynamic binding capacity at 10% breakthrough level (DBC_10%)

Proven technology

Eshmuno® CPS resin is a member of our high performance Eshmuno® platform, which is a family of chromatography resins designed to meet the demands of highly productive downstream bioprocessing processes. Eshmuno® base beads are composed of a hydrophilic polyvinyl ether polymer that enables high flow rates and therefore shorter processing times. Eshmuno® ion exchange resins also make use of our well-established tentacle ligand technology that provides a flexible multipoint interaction between the protein and resin resulting in higher binding capacities and superior selectivity.

Eshmuno® CPS can be easily packed into process scale columns, either by simple flow packing or axial compression. The pressure-flow curves for 10cm and 20cm i.d. columns at 20cm bed height are demonstrating linear scalability.


Pressure vs. flow curve Eshmuno® CPS