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324516 eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem

eEF2K Inhibitor, A-484954, CAS 142557-61-7, is a cell-permeable, highly potent, selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954

324516
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
142557-61-7C₁₃H₁₅N₅O₃

Products

Catalogue NumberPackaging Qty/Pack
324516-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
Catalogue Number324516
Brand Family Calbiochem®
Synonyms7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
References
ReferencesChen, Z., et al. 2011. J. Bio. Chem. 286, 43951.
Product Information
CAS number142557-61-7
FormOff-white powder
Hill FormulaC₁₃H₁₅N₅O₃
Chemical formulaC₁₃H₁₅N₅O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationeEF2K Inhibitor, A-484954, CAS 142557-61-7, is a cell-permeable, highly potent, selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM).
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324516-10MG 04055977197310

Documentation

eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem Certificates of Analysis

TitleLot Number
324516

References

Reference overview
Chen, Z., et al. 2011. J. Bio. Chem. 286, 43951.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-July-2012 JSW
Synonyms7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
DescriptionA cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number142557-61-7
Chemical formulaC₁₃H₁₅N₅O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (2.5 mg/ml; clear, colorless solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChen, Z., et al. 2011. J. Bio. Chem. 286, 43951.