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691400 Zebularine - CAS 3690-10-6 - Calbiochem

A cell-permeable chemically stable cytidine analog that displays antitumor properties.

Zebularine - CAS 3690-10-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside

Primary Target: Cytidine deaminase
691400
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
3690-10-6C₉H₁₂N₂O₅

Products

Catalogue NumberPackaging Qty/Pack
691400-10MG Plastic ampoule 10 mg
691400-25MG Plastic ampoule 25 mg
Description
OverviewA cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
Catalogue Number691400
Brand Family Calbiochem®
Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
References
ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
Frick, L., et al. 1989. Biochemistry 28, 9423.
Product Information
CAS number3690-10-6
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₉H₁₂N₂O₅
Chemical formulaC₉H₁₂N₂O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCytidine deaminase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


From Catalog:
Desc. Field- added "cell-permeable
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
691400-10MG 04055977225105
691400-25MG 04055977225112

Documentation

Zebularine - CAS 3690-10-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Zebularine - CAS 3690-10-6 - Calbiochem Certificates of Analysis

TitleLot Number
691400

References

Reference overview
Cheng, J.C., et al. 2004. Cancer Cell 6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
Frick, L., et al. 1989. Biochemistry 28, 9423.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-September-2008 RFH
Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
DescriptionA chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number3690-10-6
Chemical formulaC₉H₁₂N₂O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml). Slight warming may be required to achieve complete solubilization.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


From Catalog:
Desc. Field- added "cell-permeable
Toxicity Standard Handling
ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
Frick, L., et al. 1989. Biochemistry 28, 9423.