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679101 Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem

CAS 32222-06-3 prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,25-(OH)₂-D₃, Calcitriol

679101
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Overview

Key Spec Table

CAS #Empirical Formula
32222-06-3C₂₇H₄₄O₃

Products

Catalogue NumberPackaging Qty/Pack
679101-50UG Glass bottle 50 μg
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Description
OverviewHas immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes. Regulates c-myc transcription. Induces reversible hydrolysis of sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Also available as a 1 mM solution in DMSO (Cat. No. 509721).
Catalogue Number679101
Brand Family Calbiochem®
Synonyms1,25-(OH)₂-D₃, Calcitriol
References
ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Mathieu, C., et al. 1994. Diabetologica 37, 552.
Thomasset, M. 1994. Pathol. Biol. 42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
Product Information
CAS number32222-06-3
FormSolid
Hill FormulaC₂₇H₄₄O₃
Chemical formulaC₂₇H₄₄O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Safety Information according to GHS
RTECSFZ4645000
Safety Information
R PhraseR: 26/27/28-63

Very toxic by inhalation, in contact with skin and if swallowed.
Possible risk of harm to the unborn child.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
679101-50UG 07790788052348