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648485 TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HC-030031

648485
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
349085-38-7C₁₈H₂₁N₅O₃

Products

Catalogue NumberPackaging Qty/Pack
648485-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
Catalogue Number648485
Brand Family Calbiochem®
SynonymsHC-030031
References
ReferencesTaylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.
Product Information
CAS number349085-38-7
FormWhite solid
Hill FormulaC₁₈H₂₁N₅O₃
Chemical formulaC₁₈H₂₁N₅O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
648485-10MG 04055977185058

Documentation

TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem Certificates of Analysis

TitleLot Number
648485

References

Reference overview
Taylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-May-2012 JSW
SynonymsHC-030031
DescriptionA cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number349085-38-7
Chemical formulaC₁₈H₂₁N₅O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml; clear, colorless solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTaylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.