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616454 TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem

TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV

Primary Target: ALK-4/5/7
616454
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Overview

Key Spec Table

CAS #Empirical Formula
909910-43-6C₂₅H₁₉N₅S

Products

Catalogue NumberPackaging Qty/Pack
616454-2MG Plastic ampoule 2 mg
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Description
OverviewA cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
Catalogue Number616454
Brand Family Calbiochem®
SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
References
ReferencesTojo, M., et al. 2005. Cancer Sci. 96, 791.
Product Information
CAS number909910-43-6
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₂₅H₁₉N₅S
Chemical formulaC₂₅H₁₉N₅S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Biological Information
Primary TargetALK-4/5/7
Primary Target IC<sub>50</sub>45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
616454-2MG 04055977185867